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GPR35 agonists (YE120, zaprinast, and pamoic acid) promoted wound repair in the focus-dependent manner independently of cell proliferation, whereas a certain GPR35 antagonist CID2745687, forskolin, and pertussis toxin reversed the YE120-induced outcome. YE120 increased the mRNA expression of fibronectin and its receptor integrin α5, and ERK1/2 pho
The necessity of the overexpression of MNK1 or MNK2 in development and survival in cancer could depend on the balance in between both protein kinases in each tissue, together with the ratio involving the spliced isoforms a and b. So, Maimon et al. have discovered the expression of MNK2a is reduced in breast, lung, and colon tumors, while MNK2b is c